- The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers.
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Kieun Moon, Sook Hee Sung, Youn Koun Chang, Il Keun Park, Yun Mi Paek, Soo Geun Kim, Tae In Choi, Young Woo Jin
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J Prev Med Public Health. 2010;43(3):213-221.
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DOI: https://doi.org/10.3961/jpmph.2010.43.3.213
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4,882
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 Abstract
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- OBJECTIVES
Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. METHODS: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. RESULTS: The relative frequencies of alleles E2, E3 and E4 for the study population (n=305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. CONCLUSIONS: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.
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Summary
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Citations
Citations to this article as recorded by  - Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis
Sung Ryul Yu, Kyung-A Shin
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 495. CrossRef - Association between Hypertriglyceridemic-Waist Phenotype and Metabolic Abnormalities in Hypertensive Adults
Kyung-A SHIN, Myung Shin KANG
Korean Journal of Clinical Laboratory Science.2023; 55(2): 113. CrossRef - Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults
Yaling Li, Rui Zheng, Shuting Li, Ruyi Cai, Feihua Ni, Huiyan Zheng, Ruying Hu, Ting Sun
Frontiers in Endocrinology.2022;[Epub] CrossRef - Shared genetic risk factors for depression and stroke
Fuying Zhao, Yingying Yue, Haitang Jiang, Yonggui Yuan
Progress in Neuro-Psychopharmacology and Biological Psychiatry.2019; 93: 55. CrossRef - Assessing a Body Shape Index and Waist to Height Ratio as a Risk Predictor for Insulin Resistance and Metabolic Syndrome among Korean Adults
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2018; 50(1): 44. CrossRef - Clinical Usefulness of Serum Uric Acid and Resting Heart Rate in the Diagnosis of Metabolic Syndrome in Korean Adults
Kyung-A Shin
Biomedical Science Letters.2017; 23(2): 118. CrossRef - The Association of Pulse Pressure and Pre-Metabolic Syndrome in Korean Middle Aged Men
Kyung-A Shin
Biomedical Science Letters.2017; 23(2): 73. CrossRef - The Clinical Implications of Hepatic Enzymes in Metabolically Healthy Obese Men
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2017; 49(3): 248. CrossRef - Relationship between the Lipid Accumulation Product Index and Alanine Aminotransferase in Korean Adult Men
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2017; 49(4): 374. CrossRef - The Differences of Metabolic Syndrome Risk Factors according to Obesity and Abdominal Obesity in Elderly Korean Women
Kyung-A Shin
The Korean Journal of Clinical Laboratory Science.2016; 48(4): 304. CrossRef
- Radiation Exposure and Cancer Mortality Among Nuclear Power Plant Workers: a Meta-analysis.
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Eun Sook Park, Kieun Moon, Han Na Kim, Won Jin Lee, Young Woo Jin
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J Prev Med Public Health. 2010;43(2):185-192.
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DOI: https://doi.org/10.3961/jpmph.2010.43.2.185
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5,649
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279
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Abstract
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- OBJECTIVES
We conducted a meta-analysis to investigate the relationship between low external doses of ionizing radiation exposure and the risk of cancer mortality among nuclear power plant workers. METHODS: We searched MEDLINE using key words related to low dose and cancer risk. The selected articles were restricted to those written in English from 1990 to January 2009. We excluded those studies with no fit to the selection criteria and we included the cited references in published articles to minimize publication bias. Through this process, a total of 11 epidemiologic studies were finally included. RESULTS: We found significant decreased deaths from all cancers (SMR = 0.75, 95% CI = 0.62 - 0.90), all cancers excluding leukemia, solid cancer, mouth and pharynx, esophagus, stomach, rectum, liver and gallbladder, pancreas, lung, prostate, lymphopoietic and hematopoitic cancer. The findings of this meta-analysis were similar with those of the 15 Country Collaborative Study conducted by the International Agency for Research on Cancer. A publication bias was found only for liver and gallbladder cancer (p = 0.015). Heterogeneity was observed for all cancers, all cancers excluding leukemia, solid cancer, esophagus, colon and lung cancer. CONCLUSIONS: Our findings of low mortality for stomach, rectum, liver and gallbladder cancers may explained by the health worker effect. Yet further studies are needed to clarify the low SMR of cancers, for which there is no useful screening tool, in nuclear power plant workers.
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Summary
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Citations
Citations to this article as recorded by - Average Accumulated Radiation Doses for Global Nuclear Workers: Low Doses, Low Effects, and Comparison with Doses for Medical Radiologists
A. N. Koterov, A. R. Tukov, L. N. Ushenkova, M. V. Kalinina, A. P. Biryukov
Biology Bulletin.2022; 49(12): 2475. CrossRef - Fiber-optic humidity sensor system for the monitoring and detection of coolant leakage in nuclear power plants
Hye Jin Kim, Hyun Young Shin, Cheol Ho Pyeon, Sin Kim, Bongsoo Lee
Nuclear Engineering and Technology.2020; 52(8): 1689. CrossRef - Occupational Risk Factors for Prostate Cancer: A Meta-analysis
Srmena Krstev, Anders Knutsson
Journal of Cancer Prevention.2019; 24(2): 91. CrossRef - An Update on Occupation and Prostate Cancer
Glenn Doolan, Geza Benke, Graham Giles
Asian Pacific Journal of Cancer Prevention.2014; 15(2): 501. CrossRef
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